Effects of exenatide and liraglutide on heart rate, blood pressure and body weight: systematic review and meta-analysis.

ABSTRACT:

Objectives

To synthesise current evidence for the effects of exenatide and liraglutide on heart rate, blood pressure and body weight.

Design

Meta-analysis of available data from randomised controlled trials comparing Glucagon-like peptide-1 (GLP-1) analogues with placebo, active antidiabetic drug therapy or lifestyle intervention.

Participants

Patients with type 2 diabetes.

Outcome measures

Weighted mean differences between trial arms for changes in heart rate, blood pressure and body weight, after a minimum of 12-week follow-up.

Results

32 trials were included. Overall, GLP-1 agonists increased the heart rate by 1.86 beats/min (bpm) (95% CI 0.85 to 2.87) versus placebo and 1.90 bpm (1.30 to 2.50) versus active control. This effect was more evident for l

SUBMITTER: Robinson LE 

PROVIDER: S-EPMC3563145 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature