Novel candidate genes and regions for childhood apraxia of speech identified by array comparative genomic hybridization.

ABSTRACT:

Purpose

The goal of this study was to identify new candidate genes and genomic copy-number variations associated with a rare, severe, and persistent speech disorder termed childhood apraxia of speech. Childhood apraxia of speech is the speech disorder segregating with a mutation in FOXP2 in a multigenerational London pedigree widely studied for its role in the development of speech-language in humans.

Methods

A total of 24 participants who were suspected to have childhood apraxia of speech were assessed using a comprehensive protocol that samples speech in challenging contexts. All participants met clinical-research criteria for childhood apraxia of speech. Array comparative genomic hybridization analyses were completed using a customized 385K Nimblegen array (Roche Nimblege

SUBMITTER: Laffin JJ 

PROVIDER: S-EPMC3563158 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature