Wavelet-based detection of transcriptional activity on a novel Staphylococcus aureus tiling microarray.

ABSTRACT:

Background

High-density oligonucleotide microarray is an appropriate technology for genomic analysis, and is particulary useful in the generation of transcriptional maps, ChIP-on-chip studies and re-sequencing of the genome.Transcriptome analysis of tiling microarray data facilitates the discovery of novel transcripts and the assessment of differential expression in diverse experimental conditions. Although new technologies such as next-generation sequencing have appeared, microarrays might still be useful for the study of small genomes or for the analysis of genomic regions with custom microarrays due to their lower price and good accuracy in expression quantification.

Results

Here, we propose a novel wavelet-based method, named ZCL (zero-crossing lines), for the combined d

SUBMITTER: Segura V 

PROVIDER: S-EPMC3563573 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature