Dendritic cells are the major antigen presenting cells in inflammatory lesions of murine Mycoplasma respiratory disease.

ABSTRACT: Mycoplasmas cause chronic respiratory diseases in animals and humans, and to date, development of vaccines have been problematic. Using a murine model of mycoplasma pneumonia, lymphocyte responses, specifically T cells, were shown to confer protection as well as promote immunopathology in mycoplasma disease. Because T cells play such a critical role, it is important to define the role of antigen presenting cells (APC) as these cells may influence either exacerbation of mycoplasma disease pathogenesis or enhancement of protective immunity. The roles of APC, such as dendritic cells and/or macrophages, and their ability to modulate adaptive immunity in mycoplasma disease are currently unknown. Therefore, the purpose of this study was to identify individual pulmonary APC populations that may c

SUBMITTER: Sun X 

PROVIDER: S-EPMC3563630 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature