Nicotinic acetylcholine receptor variation and response to smoking cessation therapies.

ABSTRACT:

Objective

To evaluate the association of nicotinic acetylcholine receptor (nAChR) single nucleotide polymorphism (SNP) with 7-day point prevalence abstinence (abstinence) in randomized clinical trials of smoking cessation therapies in individuals grouped by pharmacotherapy randomization to inform the development of personalized smoking cessation therapy.

Materials and methods

We quantified association of four SNPs at three nAChRs with abstinence in eight randomized clinical trials. Participants were 2633 outpatient treatment-seeking, self-identified European ancestry individuals smoking at least 10 cigarettes/day, recruited through advertisement, prescribed pharmacotherapy, and provided with behavioral therapy. Interventions included nicotine replacement therapy (NRT), bupro

SUBMITTER: Bergen AW 

PROVIDER: S-EPMC3563676 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature