An fMRI study of episodic encoding across the lifespan: changes in subsequent memory effects are evident by middle-age.

ABSTRACT: Although it is well-documented that there are age differences between young and older adults in neural activity associated with successful memory formation (positive subsequent memory effects), little is known about how this activation differs across the lifespan, as few studies have included middle-aged adults. The present study investigated the effect of age on neural activity during episodic encoding using a cross-sectional lifespan sample (20-79 years old, N=192) from the Dallas Lifespan Brain Study. We report four major findings. First, in a contrast of remembered vs. forgotten items, a decrease in neural activity occurred with age in bilateral occipito-temporo-parietal regions. Second, when we contrasted forgotten with remembered items (negative subsequent memory), the primary differ

SUBMITTER: Park H 

PROVIDER: S-EPMC3563761 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature