Ontology highlight
ABSTRACT:
SUBMITTER: Klattenhoff CA
PROVIDER: S-EPMC3563769 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Cell 20130124 3
Long noncoding RNAs (lncRNAs) are often expressed in a development-specific manner, yet little is known about their roles in lineage commitment. Here, we identified Braveheart (Bvht), a heart-associated lncRNA in mouse. Using multiple embryonic stem cell (ESC) differentiation strategies, we show that Bvht is required for progression of nascent mesoderm toward a cardiac fate. We find that Bvht is necessary for activation of a core cardiovascular gene network and functions upstream of mesoderm pos ...[more]