Prenatal and infant exposures and age at menarche.

ABSTRACT:

Background

Early menarche is related to increased risk of breast cancer. The number of established factors that contribute to early menarche is limited. We studied prenatal and infant exposures in relation to age at menarche in a nationwide cohort of women who have a family history of breast cancer.

Methods

The study comprised 33,501 women in the Sister Study who were 35-59 years of age at baseline (2003-2009). We used polytomous logistic regression to estimate separate relative risk ratios (rRRs) and 95% confidence intervals (CIs) for associations of self-reported exposures with menarche at ≤10, 11, 14, and ≥15 years relative to menarche at 12-13 years.

Results

Early menarche (≤10 or 11 years) was associated with having low birth weight, having had a teenage mother,

SUBMITTER: D'Aloisio AA 

PROVIDER: S-EPMC3563843 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature