MRI-based biodistribution assessment of holmium-166 poly(L-lactic acid) microspheres after radioembolisation.

ABSTRACT:

Objectives

To demonstrate the feasibility of MRI-based assessment of the intrahepatic Ho-PLLA-MS biodistribution after radioembolisation in order to estimate the absorbed radiation dose.

Methods

Fifteen patients were treated with holmium-166 ((166)Ho) poly(L-lactic acid)-loaded microspheres (Ho-PLLA-MS, mean 484 mg; range 408-593 mg) in a phase I study. Multi-echo gradient-echo MR images were acquired from which R (2) maps were constructed. The amount of Ho-PLLA-MS in the liver was determined by using the relaxivity r (2) of the Ho-PLLA-MS and compared with the administered amount. Quantitative single photon emission computed tomography (SPECT) was used for comparison with MRI regarding the whole liver absorbed radiation dose.

Results

R (2) maps visualised the deposit

SUBMITTER: van de Maat GH 

PROVIDER: S-EPMC3563959 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature