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A new spatane diterpenoid from the cultured soft coral Sinularia leptoclados.

ABSTRACT: A new spatane diterpenoid, leptoclalin A (1), along with two previously reported known norcembranoid diterpenes (2 and 3), were isolated from a cultured soft coral Sinularia leptoclados. The structures were determined by extensive spectroscopic analyses and by comparison with the spectral data of related known compounds. Metabolite 1 is rarely found in spatane skeletons reported from soft corals. In addition, compound 1 exhibited weak cytotoxicity towards human tumor cell lines T-47 D and K-562.

SUBMITTER: Tsai TC 

PROVIDER: S-EPMC3564161 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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A new spatane diterpenoid from the cultured soft coral Sinularia leptoclados.

Tsai Tsung-Chang TC   Wu Yu-Jen YJ   Su Jui-Hsin JH   Lin Wei-Tung WT   Lin Yun-Sheng YS  

Marine drugs 20130110 1

A new spatane diterpenoid, leptoclalin A (1), along with two previously reported known norcembranoid diterpenes (2 and 3), were isolated from a cultured soft coral Sinularia leptoclados. The structures were determined by extensive spectroscopic analyses and by comparison with the spectral data of related known compounds. Metabolite 1 is rarely found in spatane skeletons reported from soft corals. In addition, compound 1 exhibited weak cytotoxicity towards human tumor cell lines T-47 D and K-562. ...[more]

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