The histone methyltransferase inhibitor BIX01294 enhances the cardiac potential of bone marrow cells.

ABSTRACT: Bone marrow (BM) has long been considered a potential stem cell source for cardiac repair due to its abundance and accessibility. Although previous investigations have generated cardiomyocytes from BM, yields have been low, and far less than produced from ES or induced pluripotent stem cells (iPSCs). Since differentiation of pluripotent cells is difficult to control, we investigated whether BM cardiac competency could be enhanced without making cells pluripotent. From screens of various molecules that have been shown to assist iPSC production or maintain the ES cell phenotype, we identified the G9a histone methyltransferase inhibitor BIX01294 as a potential reprogramming agent for converting BM cells to a cardiac-competent phenotype. BM cells exposed to BIX01294 displayed significantly ele

SUBMITTER: Mezentseva NV 

PROVIDER: S-EPMC3564468 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature