New platelet glycoprotein polymorphisms causing maternal immunization and neonatal alloimmune thrombocytopenia.

ABSTRACT:

Background

Maternal immunization against low-frequency, platelet (PLT)-specific antigens is being recognized with increasing frequency as a cause of neonatal alloimmune thrombocytopenia (NAIT).

Study design and methods

Serologic and molecular studies were performed on PLTs and DNA from two families in which an infant was born with severe thrombocytopenia not attributable to maternal immunization against known PLT-specific alloantigens.

Results

Antibodies reactive only with paternal PLTs were identified in each mother using flow cytometry and solid-phase assays. Unique mutations encoding amino acid substitutions K164T in glycoprotein (GP)IIb (Case 1) and R622W in GPIIIa (Case 2) were identified in paternal DNA and in DNA from the affected infants. Each maternal antibod

SUBMITTER: Peterson JA 

PROVIDER: S-EPMC3564505 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature