A genome-wide transcriptional analysis of morphology determination in Candida albicans.

ABSTRACT: Candida albicans, the most common cause of human fungal infections, undergoes a reversible morphological transition from yeast to pseudohyphal and hyphal filaments, which is required for virulence. For many years, the relationship among global gene expression patterns associated with determination of specific C. albicans morphologies has remained obscure. Using a strain that can be genetically manipulated to sequentially transition from yeast to pseudohyphae to hyphae in the absence of complex environmental cues and upstream signaling pathways, we demonstrate by whole-genome transcriptional profiling that genes associated with pseudohyphae represent a subset of those associated with hyphae and are generally expressed at lower levels. Our results also strongly suggest that in addition to do

SUBMITTER: Carlisle PL 

PROVIDER: S-EPMC3564527 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature