Ontology highlight
ABSTRACT:
SUBMITTER: Cho SW
PROVIDER: S-EPMC3564673 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Cho Seung-Woo SW Goldberg Michael M Son Sun Mi SM Xu Qiaobing Q Yang Fan F Mei Ying Y Bogatyrev Said S Langer Robert R Anderson Daniel G DG
Advanced functional materials 20090825 19
Here we develop nanoparticles composed of lipid-like materials (lipidoids) to facilitate non-viral delivery of small interfering RNA (siRNA) to endothelial cells (ECs). Nanoparticles composed of siRNA and lipidoids with small size (~200 nm) and positive charge (~34 mV) were formed by self assembly of lipidoids and siRNA. Ten lipidoids were synthesized and screened for their ability to facilitate the delivery of siRNA into ECs. Particles composed of leading lipidoids show significantly better del ...[more]