The lack of autophagy triggers precocious activation of Notch signaling during Drosophila oogenesis.

ABSTRACT:

Background

The proper balance of autophagy, a lysosome-mediated degradation process, is indispensable for oogenesis in Drosophila. We recently demonstrated that egg development depends on autophagy in the somatic follicle cells (FC), but not in the germline cells (GCs). However, the lack of autophagy only affects oogenesis when FCs are autophagy-deficient but GCs are wild type, indicating that a dysfunctional signaling between soma and germline may be responsible for the oogenesis defects. Thus, autophagy could play an essential role in modulating signal transduction pathways during egg development.

Results

Here, we provide further evidence for the necessity of autophagy during oogenesis and demonstrate that autophagy is especially required in subsets of FCs. Generation of a

SUBMITTER: Barth JM 

PROVIDER: S-EPMC3564699 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature