Lack of association between a functional variant of the BRCA-1 related associated protein (BRAP) gene and ischemic stroke.

ABSTRACT:

Background

Atherosclerosis shares common pathogenic features with myocardial infarction (MI) and ischemic stroke. BRCA-1 associated protein (BRAP), a newly identified risk gene for MI, aggravates the inflammatory response in atherosclerosis. The aim of this study was to test the association between the BRAP gene and stroke in a Taiwanese population.

Methods

A total of 1,074 stroke patients and 1,936 controls were genotyped for the functional SNP rs11066001. In our previous studies, the rare allele of this SNP has been repeatedly shown to exert a recessive effect. Therefore, in the current study, we tested for the same recessive model. First, the genotype distributions between all the controls and all the stroke cases were compared. Then to reduce heterogeneity, we explored s

SUBMITTER: Liao YC 

PROVIDER: S-EPMC3564782 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature