IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice.

ABSTRACT:

Background

Pulmonary emphysema is characterized by alveolar destruction and persistent inflammation of the airways. Although IL-17A contributes to many chronic inflammatory diseases, it's role in the inflammatory response of elastase-induced emphysema remains unclear.

Methods

In a model of elastase-induced pulmonary emphysema we examined the response of IL-17A-deficient mice, monitoring airway inflammation, static compliance, lung histology and levels of neutrophil-related chemokine and pro-inflammatory cytokines in bronchoalveolar lavage (BAL) fluid.

Results

Wild-type mice developed emphysematous changes in the lung tissue on day 21 after elastase treatment, whereas emphysematous changes were decreased in IL-17A-deficient mice compared to wild-type mice. Neutrophilia

SUBMITTER: Kurimoto E 

PROVIDER: S-EPMC3564829 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature