A compendium of Caenorhabditis elegans RNA binding proteins predicts extensive regulation at multiple levels.

ABSTRACT: Gene expression is regulated at multiple levels, including transcription and translation, as well as mRNA and protein stability. Although systems-level functions of transcription factors and microRNAs are rapidly being characterized, few studies have focused on the posttranscriptional gene regulation by RNA binding proteins (RBPs). RBPs are important to many aspects of gene regulation. Thus, it is essential to know which genes encode RBPs, which RBPs regulate which gene(s), and how RBP genes are themselves regulated. Here we provide a comprehensive compendium of RBPs from the nematode Caenorhabditis elegans (wRBP1.0). We predict that as many as 887 (4.4%) of C. elegans genes may encode RBPs ~250 of which likely function in a gene-specific manner. In addition, we find that RBPs, and most no

SUBMITTER: Tamburino AM 

PROVIDER: S-EPMC3564989 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature