Effects of estrogen with micronized progesterone on cortical and trabecular bone mass and microstructure in recently postmenopausal women.

ABSTRACT:

Context

In women, cortical bone mass decreases significantly at menopause. By contrast, loss of trabecular bone begins in the third decade and accelerates after menopause.

Objective

The aim of the study was to investigate the effects of estrogen on cortical and trabecular bone.

Design

The Kronos Early Estrogen Prevention Study is a double-blind, randomized, placebo-controlled trial of menopausal hormone treatment (MHT) in women, enrolled within 6-36 months of their final menstrual period.

Setting

The study was conducted at the Mayo Clinic, Rochester, Minnesota.

Intervention

Subjects were treated with placebo (n = 31), or .45 mg/d conjugated equine estrogens (n = 20), or transdermal 50 μg/d 17β-estradiol (n = 25) with pulsed micronized progesterone.

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SUBMITTER: Farr JN 

PROVIDER: S-EPMC3565106 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature