Systematic review: diet-gene interactions and the risk of colorectal cancer.

ABSTRACT:

Background

Diet contributes significantly to colorectal cancer (CRC) aetiology and may be potentially modifiable.

Aim

To review diet-gene interactions, aiming to further the understanding of the underlying biological pathways in CRC development.

Methods

The PubMed and Medline were systematically searched for prospective studies in relation to diet, colorectal cancer and genetics.

Results

In a meta-analysis, no interaction between NAT1 phenotypes and meat intake in relation to risk of CRC was found (P-value for interaction 0.95). We found a trend towards interaction between NAT2 phenotypes and meat intake in relation to risk of CRC. High meat intake was not associated with risk of CRC among carriers of the slow NAT2 phenotype, whereas NAT2 fast acetylators with

SUBMITTER: Andersen V 

PROVIDER: S-EPMC3565452 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature