An Integrative Genomics Approach for Associating GWAS Information with Triple-Negative Breast Cancer.

ABSTRACT: Genome-wide association studies (GWAS) have identified genetic variants associated with an increased risk of developing breast cancer. However, the association of genetic variants and their associated genes with the most aggressive subset of breast cancer, the triple-negative breast cancer (TNBC), remains a central puzzle in molecular epidemiology. The objective of this study was to determine whether genes containing single nucleotide polymorphisms (SNPs) associated with an increased risk of developing breast cancer are connected to and could stratify different subtypes of TNBC. Additionally, we sought to identify molecular pathways and networks involved in TNBC. We performed integrative genomics analysis, combining information from GWAS studies involving over 400,000 cases and over 400,00

SUBMITTER: Hicks C 

PROVIDER: S-EPMC3565545 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature