Levels of beta-microseminoprotein in blood and risk of prostate cancer in multiple populations.

ABSTRACT:

Background

A common genetic variant (rs10993994) in the 5' region of the gene encoding β-microseminoprotein (MSP) is associated with circulating levels of MSP and prostate cancer risk. Whether MSP levels are predictive of prostate cancer risk has not been evaluated.

Methods

We investigated the prospective relationship between circulating plasma levels of MSP and prostate cancer risk in a nested case-control study of 1503 case subjects and 1503 control subjects among black, Latino, Japanese, Native Hawaiian, and white men from the Multiethnic Cohort study. We also examined the ability of MSP to serve as a biomarker for discriminating prostate cancer case subjects from control subjects. All statistical tests are two-sided.

Results

In all racial and ethnic groups, men wi

SUBMITTER: Haiman CA 

PROVIDER: S-EPMC3565627 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature