Responder and nonresponder patients exhibit different peripheral transcriptional signatures during major depressive episode.

ABSTRACT: To date, it remains impossible to guarantee that short-term treatment given to a patient suffering from a major depressive episode (MDE) will improve long-term efficacy. Objective biological measurements and biomarkers that could help in predicting the clinical evolution of MDE are still warranted. To better understand the reason nearly half of MDE patients respond poorly to current antidepressive treatments, we examined the gene expression profile of peripheral blood samples collected from 16 severe MDE patients and 13 matched controls. Using a naturalistic and longitudinal design, we ascertained mRNA and microRNA (miRNA) expression at baseline, 2 and 8 weeks later. On a genome-wide scale, we detected transcripts with roles in various biological processes as significantly dysregulated bet

SUBMITTER: Belzeaux R 

PROVIDER: S-EPMC3565773 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature