Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response.

ABSTRACT: Despite the overt need for improved treatment modalities in depression, efforts to develop conceptually novel antidepressants have been relatively unsuccessful so far. Here we present a translational approach combining results from hypothesis-free animal experiments with data from a genetic association study in depression. Comparing genes regulated by chronic paroxetine treatment in the mouse hippocampus with genes showing nominally significant association with antidepressant treatment response in two pharmacogenetic studies, the activin pathway was the only one to show this dual pattern of association and therefore selected as a candidate. We examined the regulation of activin A and activin receptor type IA mRNA following antidepressant treatment. We investigated the effects of stereotaxi

SUBMITTER: Ganea K 

PROVIDER: S-EPMC3565812 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature