A general preparation of (Z)-1-fluorostilbene derivatives for the design of conformationally restricted peptidomimetics.

ABSTRACT: The preparation of (Z)-1-fluoro-2-bromostyrenes provides a general route for the formation of (Z)-1-fluorostilbene derivatives as configurationally stable spacial linkers for the design of conformationally restricted peptidomimetics. Palladium-catalyzed aryl Suzuki and Stille cross-coupling reactions have been surveyed to proceed with complete retention of fluoroalkene geometry, and permit the direct incorporation of a variety of aryl and heteroaromatic substituents.

SUBMITTER: Williams DR 

PROVIDER: S-EPMC3565843 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature