TNF gene polymorphisms in cystic fibrosis patients: contribution to the disease progression.

ABSTRACT:

Background

It is well known that the disease progression in cystic fibrosis (CF) patients may be diverse in subjects with identical mutation in CFTR gene. It is quite possible that such heterogeneity is associated with TNF-α and/or LT-α gene polymorphisms since their products play a key role in inflammation. The aim of the study was to investigate the possible roles of TNF gene polymorphisms in CF disease phenotype and progression.

Methods

198 CF patients and 130 control subjects were genotyped for both TNF-α-308GA and LT-α + 252AG polymorphisms.

Results

The carriers of the TNF-α-308A allele more frequently had asthma as compared to patients homozygous for the TNF-α-308 G allele. In 9 of 108 (8.3%) of LTα + 252AA carriers, tuberculosis infection has been documented, w

SUBMITTER: Shmarina G 

PROVIDER: S-EPMC3565881 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature