A high-dimensional, deep-sequencing study of lung adenocarcinoma in female never-smokers.

ABSTRACT:

Background

Deep sequencing techniques provide a remarkable opportunity for comprehensive understanding of tumorigenesis at the molecular level. As omics studies become popular, integrative approaches need to be developed to move from a simple cataloguing of mutations and changes in gene expression to dissecting the molecular nature of carcinogenesis at the systemic level and understanding the complex networks that lead to cancer development.

Results

Here, we describe a high-throughput, multi-dimensional sequencing study of primary lung adenocarcinoma tumors and adjacent normal tissues of six Korean female never-smoker patients. Our data encompass results from exome-seq, RNA-seq, small RNA-seq, and MeDIP-seq. We identified and validated novel genetic aberrations, including 47

SUBMITTER: Kim SC 

PROVIDER: S-EPMC3566005 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature