Nuclear nano-morphology markers of histologically normal cells detect the "field effect" of breast cancer.

ABSTRACT: Accurate detection of breast malignancy from histologically normal cells ("field effect") has significant clinical implications in a broad base of breast cancer management, such as high-risk lesion management, personalized risk assessment, breast tumor recurrence, and tumor margin management. More accurate and clinically applicable tools to detect markers characteristic of breast cancer "field effect" that are able to guide the clinical management are urgently needed. We have recently developed a novel optical microscope, spatial-domain low-coherence quantitative phase microscopy, which extracts the nanoscale structural characteristics of cell nuclei (i.e., nuclear nano-morphology markers), using standard histology slides. In this proof-of-concept study, we present the use of these highly

SUBMITTER: Bista RK 

PROVIDER: S-EPMC3566261 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature