Sex-biased networks and nodes of sexually antagonistic conflict in Drosophila.

ABSTRACT: Sexual antagonism, or conflict, can occur when males and females harbor opposing reproductive strategies. The large fraction of sex-biased genes in genomes present considerable opportunities for conflict to occur, suggesting that sexual antagonism may potentially be a general phenomenon at the molecular level. Here, we employ a novel strategy to identify potential nodes of sexual conflict in Drosophila melanogaster by coupling male, female, and sex-unbiased networks derived from genome-wide expression data with available genetic and protein interaction data. We find that sex-biased networks comprise a large fraction (~1/3) of the total interaction network with the male network possessing nearly twice the number of nodes (genes) relative to the female network. However, there are far less ed

SUBMITTER: Hansen ME 

PROVIDER: S-EPMC3566611 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature