Statins and outcomes in patients with bloodstream infection: a propensity-matched analysis.

ABSTRACT:

Objective

The pleiotropic effects of statins, 3-hydroxy-3 methylglutaryl coenzyme A reductase inhibitor, have been shown to modify inflammatory cell signaling on the immune response to infection. It was postulated that statins may be a good candidate as novel therapeutic agents for the treatment of sepsis. We investigated whether ongoing statin therapy is associated with mortality in patients with bloodstream infection.

Design

A retrospective cohort study.

Setting

Two tertiary hospitals in Bronx, NY.

Patients

Adult patients in the hospital with bloodstream infection and categorized according to statin therapy as an outpatient or inpatient before bacteremia.

Interventions

None.

Measurement and main results

Of 2,139 bacteremic hospitalized patients,

SUBMITTER: Leung S 

PROVIDER: S-EPMC3566662 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature