Sensitivity analysis for nonignorable missingness and outcome misclassification from proxy reports.

ABSTRACT: Researchers often recruit proxy respondents, such as relatives or caregivers, for epidemiologic studies of older adults when study participants are unable to provide self-reports (eg, because of illness or cognitive impairment). In most studies involving proxy-reported outcomes, proxies are recruited only to report on behalf of participants who have missing self-reported outcomes; thus, either a proxy report or participant self-report, but not both, is available for each participant. When outcomes are binary and investigators conceptualize participant self-reports as gold standard measures, substituting proxy reports in place of missing participant self-reports in statistical analysis can introduce misclassification error and lead to biased parameter estimates. However, excluding observati

SUBMITTER: Shardell M 

PROVIDER: S-EPMC3566762 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature