Immunomodulation and the quorum sensing molecule 3-oxo-C12-homoserine lactone: the importance of chemical scaffolding for probe development.

ABSTRACT: As a guide for chemical probe design, focused analogue synthetic studies were undertaken upon the lactone ring of 3-oxo-C(12)-homoserine lactone. We have concluded that hydrolytic instability of the heterocyclic ring is pivotal for its ability to modulate immune signaling and probe preparation was aligned with these findings.

SUBMITTER: Garner AL 

PROVIDER: S-EPMC3566768 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature