Clinical impact of circulating miR-221 in plasma of patients with pancreatic cancer.

ABSTRACT:

Background

Several recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in plasma/serum. We tested miR-221 and miR-375, which are frequently reported to be highly and poorly expressed in pancreatic cancer (PCa), as candidates for plasma biomarkers in PCa.

Methods

This study was divided into three parts: (1) Confirmation of higher miR-221 levels in primary PCa tissue and cell lines than normal pancreatic tissues. (2) Evaluation of plasma miR-221 and miR-375 concentrations by comparing results from 47 consecutive PCa patients and 30 healthy volunteers. (3) Evaluation of the assay for monitoring tumour dynamics in PCa patients.

Results

(1) Expression of miR-221 was significantly higher in PCa tissues and cell lines than normal pancreatic tissues

SUBMITTER: Kawaguchi T 

PROVIDER: S-EPMC3566805 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature