The epigenetic landscape of oral squamous cell carcinoma.

ABSTRACT:

Background

There is relatively little methylation array data available specifically for oral squamous cell carcinoma (OSCC). This study aims to compare the DNA methylome across a large cohort of tumour/normal pairs.

Methods

DNA was extracted from 44 OSCCs and paired normal mucosa. DNA methylation analysis employed the Illumina GoldenGate high-throughput array comprising 1505 CpG loci selected from 807 epigenetically regulated genes. This data was correlated with extracapsular spread (ECS), human papilloma virus (HPV) status, recurrence and 5-year survival.

Results

Differential methylation levels of a number of genes distinguished the tumour tissue sample from the matched normal. Putative methylation signatures for ECS and recurrence were identified. The concept of con

SUBMITTER: Jithesh PV 

PROVIDER: S-EPMC3566828 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature