Drosophila MOF controls Checkpoint protein2 and regulates genomic stability during early embryogenesis.

ABSTRACT:

Background

In Drosophila embryos, checkpoints maintain genome stability by delaying cell cycle progression that allows time for damage repair or to complete DNA synthesis. Drosophila MOF, a member of MYST histone acetyl transferase is an essential component of male X hyperactivation process. Until recently its involvement in G2/M cell cycle arrest and defects in ionizing radiation induced DNA damage pathways was not well established.

Results

Drosophila MOF is highly expressed during early embryogenesis. In the present study we show that haplo-insufficiency of maternal MOF leads to spontaneous mitotic defects like mitotic asynchrony, mitotic catastrophe and chromatid bridges in the syncytial embryos. Such abnormal nuclei are eliminated and digested in the yolk tissues by nucl

SUBMITTER: Pushpavalli SN 

PROVIDER: S-EPMC3566930 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature