The impact of GPX1 on the association of groundwater selenium and depression: a Project FRONTIER study.

ABSTRACT:

Background

Prior animal model and human-based studies have linked selenium concentrations to decreased risk for depression; however, this work has not focused on household groundwater levels or specific depressive symptoms. The current study evaluated the link between groundwater selenium levels and depression. We also sought to determine if a functional polymorphism in the glutathione peroxidase 1 (GPX1) gene impacted this link.

Methods

We used a cross-sectional design to analyze data from 585 participants (183 men and 402 women) from Project FRONTIER, a study of rural health in West Texas. Residential selenium concentrations were estimated using Geospatial Information System (GIS) analyses. Linear regression models were created using Geriatric Depression Scale (GDS-30) tot

SUBMITTER: Johnson LA 

PROVIDER: S-EPMC3566946 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature