Experimental gingivitis induces systemic inflammatory markers in young healthy individuals: a single-subject interventional study.

ABSTRACT:

Objectives

We here investigated whether experimental gingivitis enhances systemic markers of inflammation which are also known as surrogate markers of atherosclerotic plaque development.

Background

Gingivitis is a low-level oral infection induced by bacterial deposits with a high prevalence within Western populations. A potential link between the more severe oral disease periodontitis and cardiovascular disease has already been shown.

Methods

37 non-smoking young volunteers with no inflammatory disease or any cardiovascular risk factors participated in this single-subject interventional study with an intra-individual control. Intentionally experimental oral inflammation was induced by the interruption of oral hygiene for 21 days, followed by a 21-days resolving phase

SUBMITTER: Eberhard J 

PROVIDER: S-EPMC3567060 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature