Ontology highlight
ABSTRACT:
SUBMITTER: Yakhnin AV
PROVIDER: S-EPMC3567230 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Yakhnin Alexander V AV Baker Carol S CS Vakulskas Christopher A CA Yakhnin Helen H Berezin Igor I Romeo Tony T Babitzke Paul P
Molecular microbiology 20130111 4
Csr is a conserved global regulatory system that controls expression of several hundred Escherichia coli genes. CsrA protein represses translation of numerous genes by binding to mRNA and inhibiting ribosome access. CsrA also activates gene expression, although an activation mechanism has not been reported. CsrA activates flhDC expression, encoding the master regulator of flagellum biosynthesis and chemotaxis, by stabilizing the mRNA. Computer modelling, gel mobility shift and footprint analyses ...[more]