P450 monooxygenases (P450ome) of the model white rot fungus Phanerochaete chrysosporium.

ABSTRACT: Phanerochaete chrysosporium, the model white rot fungus, has been the focus of research for the past about four decades for understanding the mechanisms and processes of biodegradation of the natural aromatic polymer lignin and a broad range of environmental toxic chemicals. The ability to degrade this vast array of xenobiotic compounds was originally attributed to its lignin-degrading enzyme system, mainly the extracellular peroxidases. However, subsequent physiological, biochemical, and/or genetic studies by us and others identified the involvement of a peroxidase-independent oxidoreductase system, the cytochrome P450 monooxygenase system. The whole genome sequence revealed an extraordinarily large P450 contingent (P450ome) with an estimated 149 P450s in this organism. This review focuse

SUBMITTER: Syed K 

PROVIDER: S-EPMC3567848 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature