Transcription termination by the eukaryotic RNA polymerase III.

ABSTRACT: RNA polymerase (pol) III transcribes a multitude of tRNA and 5S rRNA genes as well as other small RNA genes distributed through the genome. By being sequence-specific, precise and efficient, transcription termination by pol III not only defines the 3' end of the nascent RNA which directs subsequent association with the stabilizing La protein, it also prevents transcription into downstream DNA and promotes efficient recycling. Each of the RNA polymerases appears to have evolved unique mechanisms to initiate the process of termination in response to different types of termination signals. However, in eukaryotes much less is known about the final stage of termination, destabilization of the elongation complex with release of the RNA and DNA from the polymerase active center. By comparison to

SUBMITTER: Arimbasseri AG 

PROVIDER: S-EPMC3568203 | biostudies-literature | 2013 Mar-Apr

REPOSITORIES: biostudies-literature