Coilin displays differential affinity for specific RNAs in vivo and is linked to telomerase RNA biogenesis.

ABSTRACT: Coilin is widely known as the protein marker of the Cajal body, a subnuclear domain important to the biogenesis of small nuclear ribonucleoproteins and telomerase, complexes that are crucial to pre-messenger RNA splicing and telomere maintenance, respectively. Extensive studies have characterized the interaction between coilin and the various other protein components of CBs and related subnuclear domains; however, only a few have examined interactions between coilin and nucleic acid. We have recently published that coilin is tightly associated with nucleic acid, displays RNase activity in vitro, and is redistributed to the ribosomal RNA (rRNA)-rich nucleoli in cells treated with the DNA-damaging agents cisplatin and etoposide. Here, we report a specific in vivo association between coilin a

SUBMITTER: Broome HJ 

PROVIDER: S-EPMC3568234 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature