Altered serum microRNAs as biomarkers for the early diagnosis of pulmonary tuberculosis infection.

ABSTRACT:

Background

Pulmonary tuberculosis (TB) is a highly lethal infectious disease and early diagnosis of TB is critical for the control of disease progression. The objective of this study was to profile a panel of serum microRNAs (miRNAs) as potential biomarkers for the early diagnosis of pulmonary TB infection.

Methods

Using TaqMan Low-Density Array (TLDA) analysis followed by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) validation, expression levels of miRNAs in serum samples from 30 patients with active tuberculosis and 60 patients with Bordetella pertussis (BP), varicella-zoster virus (VZV) and enterovirus (EV) were analyzed.

Results

The Low-Density Array data showed that 97 miRNAs were differentially expressed in pulmonary TB patient sera com

SUBMITTER: Qi Y 

PROVIDER: S-EPMC3568404 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature