Comparative effectiveness of chemotherapy in elderly patients with metastatic colorectal cancer.

ABSTRACT:

Purpose

Treatment advances have improved outcomes in clinical trials of patients with metastatic colorectal cancer (mCRC). Less is known about these effects for patients in real-world settings. This study evaluated treatment patterns and survival in older, demographically diverse patients with mCRC.

Methods

A retrospective cohort analysis was performed for 4,250 patients from January 1, 2000 to December 31, 2007 using linked Surveillance, Epidemiology, and End Results-Medicare database. Patients were ≥ 66 years, enrolled in Medicare parts A and B, and received first-line treatment with fluorouracil and leucovorin (5-FU/LV), capecitabine (CAP), 5-FU/LV plus oxaliplatin (FOLFOX), or CAP and oxaliplatin (CAPOX). Cox regression with backward elimination and propensity score-weig

SUBMITTER: Satram-Hoang S 

PROVIDER: S-EPMC3568483 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature