Rabies virus glycoprotein is an important determinant for the induction of innate immune responses and the pathogenic mechanisms.

ABSTRACT: Our previous studies have suggested that street and fixed rabies viruses (RABVs) induce diseases in the mouse model via different mechanisms. In the present study, attempts were made to determine if it is the glycoprotein (G) that is responsible for the observed differences in the pathogenic mechanisms. To this end, an infectious clone from fixed virus B2c was established and used as a backbone for exchange of the G from street viruses. The rate of viral replication, expression of viral proteins, and the induction of innate immune responses were compared in cells or in mice infected with each of the viruses. Furthermore, the infiltration of inflammatory cells into the CNS and the enhancement of blood-brain barrier (BBB) permeability were also compared. It was found that fixed viruses induc

SUBMITTER: Zhang G 

PROVIDER: S-EPMC3568536 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature