MUC4 overexpression augments cell migration and metastasis through EGFR family proteins in triple negative breast cancer cells.

ABSTRACT:

Introduction

Current studies indicate that triple negative breast cancer (TNBC), an aggressive breast cancer subtype, is associated with poor prognosis and an early pattern of metastasis. Emerging evidence suggests that MUC4 mucin is associated with metastasis of various cancers, including breast cancer. However, the functional role of MUC4 remains unclear in breast cancers, especially in TNBCs.

Method

In the present study, we investigated the functional and mechanistic roles of MUC4 in potentiating pathogenic signals including EGFR family proteins to promote TNBC aggressiveness using in vitro and in vivo studies. Further, we studied the expression of MUC4 in invasive TNBC tissue and normal breast tissue by immunostaining.

Results

MUC4 promotes proliferation, anchorag

SUBMITTER: Mukhopadhyay P 

PROVIDER: S-EPMC3569463 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature