Efficacy of NNRTI-based antiretroviral therapy initiated during acute HIV infection.

ABSTRACT:

Objective

Characterize responses to non-nucleoside reverse transcriptase inhibitor (NNRTI)-based antiretroviral treatment (ART) initiated during acute HIV infection (AHI).

Design

This was a prospective, single-arm evaluation of once-daily, co-formulated emtricitabine/tenofovir/efavirenz initiated during AHI.

Methods

The primary endpoint is the proportion of responders with HIV RNA less than 200 copies/ml by week 24. We examined time to viral suppression and CD8 cell activation in relation to baseline participant characteristics. We compared time to viral suppression and viral dynamics using linear mixed-effects models between acutely infected participants and chronically infected controls.

Results

Between January 2005 and May 2009, 61 AHI participants were enro

SUBMITTER: Gay CL 

PROVIDER: S-EPMC3569481 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature