Prediction of temperature factors from protein sequence.

ABSTRACT: Protein flexibility is useful in structural and functional aspect of proteins. We have analyzed the local primary protein sequence features that in combination can predict the B-value of amino acid residues directly from the protein sequence. We have also analyzed the distribution of B-value in different regions of protein three dimensional structures. On an average, the normalized Bvalue decreases by 0.1055 with every 0.5Å increase in the distance of the residue from protein surface. The residues in the loop regions have higher B-values as compared to the residues present in other regular secondary structural elements. Buried residues which are present in the protein core are more rigid (lower B-values) than the residues present on the protein surface. Similarly, the hydrophobic residues

SUBMITTER: Sonavane S 

PROVIDER: S-EPMC3569600 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature