In utero and childhood polybrominated diphenyl ether (PBDE) exposures and neurodevelopment in the CHAMACOS study.

ABSTRACT:

Background

California children's exposures to polybrominated diphenyl ether flame retardants (PBDEs) are among the highest worldwide. PBDEs are known endocrine disruptors and neurotoxicants in animals.

Objective

Here we investigate the relation of in utero and child PBDE exposure to neurobehavioral development among participants in CHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas), a California birth cohort.

Methods

We measured PBDEs in maternal prenatal and child serum samples and examined the association of PBDE concentrations with children's attention, motor functioning, and cognition at 5 (n = 310) and 7 years of age (n = 323).

Results

Maternal prenatal PBDE concentrations were associated with impaired attention as measured by a

SUBMITTER: Eskenazi B 

PROVIDER: S-EPMC3569691 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature