Identification and characterization of an agonistic aptamer against the T cell costimulatory receptor, OX40.

ABSTRACT: Induction of an effective immune response that can target and eliminate malignant cells or virus-infected cells requires the stimulation of antigen-specific effector T cells. A productive and long-lasting memory response requires 2 signals: a specific signal provided by antigen recognition through engagement of the T cell receptor and a secondary signal via engagement of costimulatory molecules (such as OX40) on these newly activated T cells. The OX40-OX40-ligand interaction is critical for the generation of productive effector and memory T cell functions. Thus agonistic antibodies that stimulate OX40 on activated T cells have been used as adjuvants to augment immune responses. We previously demonstrated that an aptamer modified to stimulate murine OX40 enhanced vaccine-mediated immune res

SUBMITTER: Pratico ED 

PROVIDER: S-EPMC3569954 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature