A comprehensive SNP and indel imputability database.

ABSTRACT:

Motivation

Genotype imputation has become an indispensible step in genome-wide association studies (GWAS). Imputation accuracy, directly influencing downstream analysis, has shown to be improved using re-sequencing-based reference panels; however, this comes at the cost of high computational burden due to the huge number of potentially imputable markers (tens of millions) discovered through sequencing a large number of individuals. Therefore, there is an increasing need for access to imputation quality information without actually conducting imputation. To facilitate this process, we have established a publicly available SNP and indel imputability database, aiming to provide direct access to imputation accuracy information for markers identified by the 1000 Genomes Project across f

SUBMITTER: Duan Q 

PROVIDER: S-EPMC3570215 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature